PubMed:: "Drug Administration Schedule"[Mesh] OR "Dose-Response Relationship, Drug"[Mesh] OR dose reducti*[tiab] OR drug reducti*[tiab] OR dose adjust*[tiab] OR dose reducti*[ot] OR drug reducti*[ot] OR dose adjust*[ot];; Embase.com:: 'drug dose regimen'/exp OR 'drug dose reduction'/exp OR 'dosage schedule comparison'/exp OR 'dose response'/exp OR (dose NEXT/1 reducti*):ab,ti OR (drug NEXT/1 reducti*):ab,ti OR (dose NEXT/1 adjust*):ab,ti;; Cochrane Library:: "dose reduct*":ab,ti,kw OR "drug reduct*":ab,ti,kw OR "dose adjust*":ab,ti,kw