PubMed:: "Neoplasm Metastasis"[Mesh] OR "Neoplasm Invasiveness"[Mesh] OR metast*[tiab] OR micrometast*[tiab] OR seeding*[tiab] OR circulat*[tiab] OR spread*[tiab];; Embase.com:: 'metastasis'/exp OR 'tumor invasion'/de OR 'tumor seeding'/exp OR metast*:ti,ab,kw OR micrometast*:ti,ab,kw OR seeding*:ti,ab,kw OR circulat*:ti,ab,kw OR spread*:ti,ab,kw;; Cochrane Library:: metasta* or advanced:ti,ab,kw